Symbol Name ID |
Cd3e
CD3 antigen, epsilon polypeptide MGI:88332 |
Darker colors indicate more annotations |
Human Phenotypes | Defective T cell proliferation |
Decreased circulating total IgA |
Abnormal circulating IgG level |
Decreased circulating total IgM |
Abnormal lymphocyte count |
Abnormal B cell count |
Decreased proportion of CD4-positive T cells |
Decreased proportion of CD3-positive T cells |
Lymphopenia |
Reduced natural killer cell count |
Recurrent gastroenteritis |
Recurrent otitis media |
Recurrent pneumonia |
Immunodeficiency |
Recurrent respiratory infections |
Disease(s) Associated with CD3E | |||||||||||||||
immunodeficiency 18 |
Mouse Phenotypes | increased T cell apoptosis |
abnormal thymus morphology |
small thymus |
thymus hypoplasia |
increased DN3 thymocyte number |
abnormal class switch recombination |
abnormal T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
abnormal double-negative T cell morphology |
increased double-negative T cell number |
abnormal double-positive T cell morphology |
decreased double-positive T cell number |
arrested T cell differentiation |
abnormal T cell number |
decreased CD4-positive, alpha-beta T cell number |
absent CD4-positive, alpha-beta T cells |
increased central memory CD8 positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
absent CD8-positive, alpha-beta T cells |
increased CD8-positive, alpha-beta T cell number |
absent T cells |
abnormal B cell morphology |
abnormal T cell morphology |
abnormal regulatory T cell physiology |
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Availability | Mouse Genotype | ||||||||||||||||||||||||
Cd3em1Btlr/Cd3em1Btlr | |||||||||||||||||||||||||
Cd3em2Btlr/Cd3em2Btlr | |||||||||||||||||||||||||
Cd3etm1.1Geno/Cd3etm1.1Geno | |||||||||||||||||||||||||
Cd3etm1.1Lov/Cd3etm1.1Lov | |||||||||||||||||||||||||
Cd3etm1Cpt/Cd3etm1Cpt | |||||||||||||||||||||||||
Cd3etm1Lov/Cd3etm1Lov | |||||||||||||||||||||||||
Cd3etm1Mal/Cd3etm1Mal |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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